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EC number: 603-837-5
CAS number: 134605-64-4
Freshwater: 96 hour LC50 3.9 mg a.i./L, Oncorhynchus mykiss, EPA OPP 72-1, EPA 540/9-85-006, ASTM Standard E729-88a, Drottar & Swigert 1996aSaltwater: 96 hour LC50 4.6 mg a.i./L, Cyprinidon variegatus, EPA OPP 72-3, EPA 540/9-85-009 and ASTM E729-88a, Roberts & Swigert 1996
Two studies have been provided to address short term toxicity to
fish in freshwater and one study to address acute toxicity in marine
Drottar & Swigert (1996a) and Drottar & Swigert (1996b) determined
the 96 hour LC50 for the test material in the freshwater species Oncorhynchus
mykiss and Lepomis macrochirus respectively. Both studies
were performed in freshwater under flow-through conditions. The
analytical confirmed concentrations ranged from 1.5 to 8.3 mg a.i./L in
the first study and from 1.4 to 9.3 mg a.i./L in the second study. O.
mykiss was shown to be the more sensitive species with a LC50 value
of 3.9 mg a.i./L, whereas the LC50 was determined to be greater than the
highest concentration tested for L. macrochirus, > 9.3 mg
a.i./L.. Based on mortality and clinical signs of toxicity the NOEC was
considered to be 2.5 mg a.i./L for O. mykiss and 3.6 mg a.i./L
for L. macrochirus respectively. As O. mykiss is
the standard species, and the results from this study are more worst
case, this study has been considered to be the key study for freshwater
fish and the LC50 value from this study of 3.9 mg a.i./L has been taken
forward for risk assessment.
The short-term toxicity to marine fish was determined in an acute
toxicity study performed on Cyprinodon variegates, in line with
GLP and in accordance with the standardised guidelines EPA OPP 72-3, EPA
540/9-85-090 and ASTM E729-88a. Organisms were exposed to the test
material at measured concentrations of 0.96, 1.5, 2.6, 3.9 and 4.6 mg
a.i./L under flow-through saltwater conditions for 96 hours. Under the
conditions of the test mortality was observed at concentrations ≥ 3.9 mg
a.i./L. By termination mortality had reached 5% and 50% in the 3.9 and
4.6 mg a.i./L exposure groups, respectively. Clinical and behaviour
observations were noted at concentrations ≥ 3.9 mg a.i./L including
surfacing and spotted discolouration. Based on these observation the 96
hour LC50was determined to be 4.6 mg a.i./L with 95% confidence limits
of 4.4 and 5.1mg a.i./L. The NOEC were determined to be 2.6 mg a.i./L.
The study is considered to be reliable, relevant and adequate for risk
All studies were performed to a high standard, in line with GLP
and in accordance with standardised guidelines. They have thus been
assigned a reliability score of 1 in line with the principles for
assessing data quality set out in Klimisch (1997). The available data
are deemed to be relevant, reliable and adequate for the purposes of
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