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EC number: 603-837-5
CAS number: 134605-64-4
Calculated BCF values for the test material in the edible, non edible and whole fish were 1, 6 and 4 respectively, EPA OPP 165-4, OECD 305 & EPA 540/09-88-051, Volz 2000.
Volz (2000) has been provided as the key study to address
bioaccumulation of the test material in fish. The bioaccumulation and
elimination of the test material was determined in an uptake and
depuration study conducted with Bluegill sunfish (Lepomis macrochirus).
Stable steady-state was reached in fish within about one (higher
concentration) and three weeks for the higher (0.03 mg/L) and lower
(0.003 mg/L) concentration, respectively. Measured bioconcentration
factors (as a mean of the lower and the higher concentration) for
radiolabelled test material residues in non-edible portions, edible
portions and whole fish were 114, 5 and 63, respectively. Furthermore
the calculated BCFs (as a mean of the lower and the higher
concentration, again) for the same tissues were 111, 5 and 62,
respectively. Bioconcentration factors were calculated for parent and
metabolite No. 1), based on the metabolite pattern in fish tissues at
day 34 of the accumulation. The bioconcentration factors for the parent
in non-edible portions, edible portions and the whole fish were 6, 1 and
4, for the lower, and 6, 1 and 4 for the higher concentrations,
respectively. Thus, the mean BCF for the parent is 4 for the whole fish.
The bioconcentration factors for metabolite No. 1 in non-edible
portions, edible portions and the whole fish were 74, 2 and 39, for the
lower, and 68, 3 and 39 for the higher concentration, respectively.
Thus, the mean BCF for metabolite No. 1 is 39 for the whole fish. After
termination of exposure, test material residues were rapidly eliminated
from the non-edible and edible tissues and the whole fish. The
depuration time for 90 % of the bioconcentrated radioactivity for the
whole fish was less than 2 days. Under the conditions of the test, the
test material showed only limited bioconcentration in bluegill fish, and
bioconcentrated residues were rapidly eliminated in untreated water.
The study was performed to a high standard, in line with GLP and in
accordance with standardised guidelines and has thus been assigned a
reliability score of 1 in line with the principles for assessing data
quality set out in Klimisch (1997).
The available data are considered to be complete and the conclusion that
the test material has a BCF value of 4 for the whole fish has been taken
forward for risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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