Registration Dossier
Registration Dossier
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EC number: 248-580-6 | CAS number: 27619-97-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The objective of this study was to screen the test substance in male rat liver S9 and compare the amount of parent compound remaining after 2 hour incubation compared to heat inactivated controls.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- polyfluorosulphonic acid
- IUPAC Name:
- polyfluorosulphonic acid
- Test material form:
- liquid
- Details on test material:
- - Purity: 30% in water
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: rat liver S9
Administration / exposure
- Route of administration:
- other: In vitro
- Duration and frequency of treatment / exposure:
- 2 hours
Doses / concentrations
- Dose / conc.:
- 2.5 other: µM
- Remarks:
- reaction concentration
- No. of animals per sex per dose / concentration:
- 2 replicates for test substance and heat-inactivated control, 1 replicate for positive control
- Positive control reference chemical:
- 4-nonylphenol
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- No metabolism anticipated
Applicant's summary and conclusion
- Conclusions:
- No metabolism anticipated.
- Executive summary:
The objective of this study was to screen the test substance in male rat liver S9 and compare the amount of parent compound remaining after 2 hour incubation compared to heat inactivated controls. Based on the results, no metabolism is anticipated.
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