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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The objective of this study was to screen the test substance in male rat liver S9 and compare the amount of parent compound remaining after 2 hour incubation compared to heat inactivated controls.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
polyfluorosulphonic acid
IUPAC Name:
polyfluorosulphonic acid
Test material form:
liquid
Details on test material:
- Purity: 30% in water
Radiolabelling:
no

Test animals

Species:
other: rat liver S9

Administration / exposure

Route of administration:
other: In vitro
Duration and frequency of treatment / exposure:
2 hours
Doses / concentrations
Dose / conc.:
2.5 other: µM
Remarks:
reaction concentration
No. of animals per sex per dose / concentration:
2 replicates for test substance and heat-inactivated control, 1 replicate for positive control
Positive control reference chemical:
4-nonylphenol

Results and discussion

Main ADME results
Type:
metabolism
Results:
No metabolism anticipated

Applicant's summary and conclusion

Conclusions:
No metabolism anticipated.
Executive summary:

The objective of this study was to screen the test substance in male rat liver S9 and compare the amount of parent compound remaining after 2 hour incubation compared to heat inactivated controls. Based on the results, no metabolism is anticipated.