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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

in vitro metabolism screening: The screen of the test substance in male rat liver S9 for the amount of parent compound remaining after 2 hour incubation compared to heat inactivated controls indicated, based on the results, no metabolism is anticipated.

in vivo toxicokinetics: Fat and liver were analysed for parent compound to provide an estimate of tissue:plasma ratio.

        The tissue:plasma ratio at sacrifice:

             Fat: Females all below LOQ. Male at low dose = <0.1, at high dose = 0.1

             Liver: Female plasma values below LOQ so no T:P ratio calculated. Male at low dose = 3.0, at high dose = 3.1

in vivo toxicokinetics - excretion: 65-68% of the test substance was recovered in the urine 96 hours after a single gavage dose. Half-times for urinary excretion were 20.9 and  23.75 hours via NMR and LC/MS, respectively.

Key value for chemical safety assessment

Additional information