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in vitro metabolism screening: The screen of the test substance in male rat liver S9 for the amount of parent compound remaining after 2 hour incubation compared to heat inactivated controls indicated, based on the results, no metabolism is anticipated.

in vivo toxicokinetics: Fat and liver were analysed for parent compound to provide an estimate of tissue:plasma ratio.

        The tissue:plasma ratio at sacrifice:

             Fat: Females all below LOQ. Male at low dose = <0.1, at high dose = 0.1

             Liver: Female plasma values below LOQ so no T:P ratio calculated. Male at low dose = 3.0, at high dose = 3.1

in vivo toxicokinetics - excretion: 65-68% of the test substance was recovered in the urine 96 hours after a single gavage dose. Half-times for urinary excretion were 20.9 and  23.75 hours via NMR and LC/MS, respectively.

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