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EC number: 248-580-6 | CAS number: 27619-97-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 13, 2013 to March 22, 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonic acid
- EC Number:
- 248-580-6
- EC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonic acid
- Cas Number:
- 27619-97-2
- Molecular formula:
- C8H5F13O3S
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-sulfonic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Purity: 30% Halogenated aliphatic acid
In vitro test system
- Test system:
- artificial membrane barrier model
- Details on test system:
- Principles of the Method
Corrositex® is an in vitro assay used to determine the skin corrosion potential of a test substance.
The assay is based on the ability of a corrosive test substance to pass through a biobarrier membrane and to cause a color change in the liquid Chemical Detection System (CDS). The proprietary biobarrier membrane consists of a reconstituted collagen mixture. The CDS is composed of water and pH indicator dyes. Corrositex® is conducted in three steps:
1. Qualification Step
The test substance is pre-qualified to establish compatibility with the assay. The test substance is placed directly into a vial containing the CDS. If a change in color or consistency occurs, the
test substance can be tested by using this assay.
2. Categorization Step
This step establishes the category of the test substance for use in the classification step. The test substance is placed into Vial A (containing an acid buffer) and Vial B (containing a base buffer),
and the vials are observed for a color change. A color change observed in either vial is matched to a color chart. The test substance is assigned to either Category 1 or Category 2 based on the
color change in each vial. Category 1 and Category 2 are indicative of the time scales used in the classification step.
3. Classification Step
This step determines if the test substance is a skin corrosive according to UN and DOT regulations and classifications. The test substance is applied on top of the proprietary biobarrier membrane. A color change or consistency change in the CDS beneath the membrane indicates that the test substance has passed through the membrane. The determination of corrosive/non-corrosive and the Packing Group assigned are based on the amount of time it takes the test substance to pass through the membrane. The time scales differ for Category 1 and 2.
The category assigned and the mean value of the breakthrough time for all 4 sample replicate vials determines the packing group. The following table is used to assign the appropriate
Packing Group by category and breakthrough time.
PACKING GROUP DESIGNATION
Corrositex times
Category 1 0 to 3 minutes > 3 to 60 minutes > 60 to 240 minutes > 240 minutes
Category 2 0 to 3 minutes > 3 to 30 minutes > 30 to 60 minutes > 60 minutes
Corrosive Packing Group I Corrosive Packing Group II Corrosive Packing Group III Non-Corrosive
> = greater than
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Value:
- 42.42
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: The substance is corrosive Paking group III from category 2
Any other information on results incl. tables
Breakthrough of the biobarrier occurred as follows (hour:minute:second):
Vial 1 (Test Substance): 00:45:05
Vial 2 (Test Substance): 00:43:21
Vial 3 (Test Substance): 00:40:20
Vial 4 (Test Substance): 00:42:00
Mean Value: 00:42:42
Vial 5 (Positive Control): 00:01:15
Vial 6 (Negative Control): No breakthrough
The
positive control and negative control performed as anticipated.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Under the conditions of this test, the substance is classified skin corrosive cat. 1B.
- Executive summary:
The substance was evaluated for skin corrosion potential using the In Vitro International Corrositex®assay. The results of the assay were used to determine the United Nations and Department of Transportation corrosive packing group. Corrositex® is a standardized and quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system. An aliquot of 500 µL of H-30675 was applied to each of 4 membrane discs. The test substance passed through all 4 of the membranes. The mean breakthrough time for all 4 vials was 0 hours, 42 minutes, and 42 seconds. Under the conditions of this test, the substance is corrosive and is assigned to Packing Group III (minor danger).
Based on these results, the substance is classified as skin corrosive cat. 1B, in accordance with Regulation (EC) No 1272/2008 (CLP).
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