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EC number: 245-844-2
CAS number: 23726-93-4
studies and QSAR results are available to assess the aquatic toxicity of
the registered substance.
the short-term toxicity to fish, one experimental study is available.
This study (NOACK, 2015) was performed on
the registered substance according to a OECD Guideline 203 in compliance with
this study, the test substance was
exposed to zebra fish Danio rerio at
nominal concentrations of 0.342, 0.751, 1.65, 3.64 and 8.00 mg/L,
corresponding to geometric mean measured concentrations of 0.263, 0.664,
1.34, 3.47 and 7.30 mg/L, under semi-static conditions for 96 hours,
plus one control without test substance. According to the results of
this study, the
96h-LC50 was determined at 1.09 mg/L (95% CL: 1.08 -1.10 mg/L), based on
geometric mean measured concentrations.
assess the short-term toxicity to aquatic invertebrate and algae, two
reliable QSAR results are available. The QSAR predictions
(iSafeRat holistic approach v1.4) has been validated to be compliant
with the OECD recommendations for QSAR modeling (OECD, 2004) and predict
the ecotoxicological values which would be expected when testing the
substance under experimental conditions in a laboratory following OECD
Guidelines. The ecotoxicological predictions were determined using a
validated QSAR for the Mode of Action in question, (MOA 1, non-polar
narcosis). Use of this MOA for substituted α,β-unsaturated
ketones has previously been demonstrated as acceptable in a position
paper (KREATiS, 2015; available in the Endpoint Study Records). This
QSAR is based on validated data for training sets for which the
concentrations of the test substance had been determined by chemical
analyses over the test period. According to these predictions, the
48h-EC50 value for aquatic invertebrates, based on mobility, was
determined to be 9.0 mg/L (95% CL: 8.2 - 9.9 mg/L), and the 72 -h ErC50
value for algae, based on growth rate, was determined to be 8.3 mg/L
(95% CL: 7.3 - 9.5 mg/L). The substance falls within the applicability
domain of the model.
Finally, to assess the toxicity of the
registered substance to microorganisms, one experimental study is
available. This study (NOACK, 2015) was performed on the registered substance
according to OECD Guideline 209 in compliance with GLP, under static conditions
during 3 hours. The
mean inhibition of respiration for the test item replicates were -3, 2,
12, 53 and 58% at nominal test substance concentrations of 10, 32, 100,
320 and 1000 mg/L, respectively. Therefore, the test substance is
not considered toxic up to the concentration of 32 mg/L to activated
sludge of a municipal sewage treatment plant (NOEC value). The 3h-EC10 value
was determined at 93.9 mg/L (95% CL: 81.5 -108 mg/L) and
the 3h-EC50 value was determined at 275 mg/L (95% CL: 214 -339 mg/L) of
the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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