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EC number: 245-844-2
CAS number: 23726-93-4
7.3.2/1: Mean eye irritation response data of 6 animals at each
Score at time point / Reversibility
Average time for reversion
7.3.2/2: Eye irritation response data for each animal at each
Score at time
24 h (Day 1)
0 / 0 / 0 / 0 / 0 / 0
1 / 2 / 1 / 0 / 0 / 1
1 / 1 / 1 / 0 / 0 / 1
1 / 3 / 2 / 0 / 0 / 0
48 h (Day 2)
0 / 2 / 0 / 0 / 0 / 0
0 / 1 / 0 / 0 / 0 / 0
72 h (Day 3)
Average 24, 48 and 72 h
0.33 / 1.33 / 0.33 / 0 / 0 / 0.33
0.33 / 1 / 0.33 / 0 / 0 / 0.33
0.33 / 2.33 / 0.67 / 0 / 0 / 0
Average time (unit) for reversion
an eye irritation study, 0.1 g of undiluted test material was instilled
into the right eye of 6 albino rabbits while the left eye remained
untreated and served as control. The eyes were not rinsed after the
instillation of test material. Animals were observed at 24, 48 and 72 h
after instillation of test material into eyes and then on Days 5 and 7.
The reactions in the conjunctivae (redness, chemosis and discharge), the
iris and the cornea (opacity and area involved) were scored according to
the “Illustrated guide for grading eye irritation by hazardous
calculated mean score for each animal within 3 scoring times (24, 48 and
72 h) were 0.39 for redness, 0.33 for chemosis, 0.0 for iris lesions and
0.0 for corneal opacity. The observed conjunctival reactions were fully
reversible within 5 days.
the test conditions, the test material is not classified as irritating
to the eyes according to the annex I of Regulation EC No. 1272/2008
some details on test animals and experimental conditions were missing,
this study is considered as acceptable and satisfies the requirement for
eye irritation endpoint.
supporting substance is considered adequate for read-across purpose (see
Iuclid section 13 for justification).
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