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EC number: 245-844-2
CAS number: 23726-93-4
Aquatic toxicity (including STP)
studies and QSAR results are available to assess the aquatic toxicity of
the registered substance.
the short-term toxicity to fish, one experimental study is available.
This study (NOACK, 2015) was performedon
the registered substance according to a OECD Guideline 203 in compliance
this study, the test substance was
exposed to zebra fish Danio rerio at
nominal concentrations of 0.342, 0.751, 1.65, 3.64 and 8.00 mg/L,
corresponding to geometric mean measured concentrations of 0.263, 0.664,
1.34, 3.47 and 7.30 mg/L, under semi-static conditions for 96 hours,
plus one control without test substance. According to the results of
this study, the
96h-LC50 was determined at 1.09 mg/L (95% CL: 1.08 -1.10 mg/L), based on
geometric mean measured concentrations.
assess the short-term toxicity to aquatic invertebrate and algae, two
reliable QSAR results are available.The QSAR predictions
(iSafeRat holistic approach v1.4) has been validated to be compliant
with the OECD recommendations for QSAR modeling (OECD, 2004) and predict
the ecotoxicological values which would be expected when testing the
substance under experimental conditions in a laboratory following OECD
Guidelines. The ecotoxicological predictions were determined using a
validated QSAR for the Mode of Action in question, (MOA 1, non-polar
narcosis). Use of this MOA for substitutedα,β-unsaturated
ketones has previously been demonstrated as acceptable in a position
paper (KREATiS, 2015; available in the Endpoint Study Records). This
QSAR is based on validated data for training sets for which the
concentrations of the test substance had been determined by chemical
analyses over the test period. According to these predictions, the
48h-EC50 value for aquatic invertebrates, based on mobility, was
determined to be 9.0 mg/L (95% CL: 8.2 - 9.9 mg/L), and the 72 -h ErC50
value for algae, based on growth rate, was determined to be 8.3 mg/L
(95% CL: 7.3 - 9.5 mg/L). The substance falls within the applicability
domain of the model.
Finally, to assess the toxicity of the
registered substance to microorganisms, one experimental study is
available. This study (NOACK, 2015) was performed on the registered
substance according to OECD Guideline 209 in compliance with GLP, under
static conditions during 3 hours.The
mean inhibition of respiration for the test item replicates were -3, 2,
12, 53 and 58% at nominal test substance concentrations of 10, 32, 100,
320 and 1000 mg/L, respectively. Therefore, the test substance is
not considered toxic up to the concentration of 32 mg/L to activated
sludge of a municipal sewage treatment plant (NOEC value). The 3h-EC10
value was determined at 93.9 mg/L (95% CL: 81.5 -108 mg/L)and
the 3h-EC50 value was determined at 275 mg/L (95% CL: 214 -339 mg/L) of
the test substance.
Sediment, terrestrial toxicity and
hazard for predators
In the absence of any ecotoxicological data
for sediment-dwelling/soil organisms, the PNEC sediment/soil were
calculated using the equilibrium partitioning method (EPM). Furthermore,
no toxicity studies reporting the secondary poisoning effects on bird
were available, therefore the 90-day repeated dose toxicity study
performed on a read-across substance was used to derive the PNECoral.
Environmental fate and pathways
The registered substance is not considered
readily biodegradable due to the 10-day window not fulfilled, and is
considered hydrolytically stable at environmentally relevant pH.
However, as 77% biodegradation was observed after 48 days of exposure in
the biodegradation study, the substance is not considered persistent.
The registered substance is considered environmentally low mobile in
soils (according to P.J. McCall et al., 1980) with an estimated Koc
value at 759.7 L/kg (log Koc = 2.88) and is not considered
bioaccumulable. Indeed, the experimental BCF value is comprised between
14 and 56, well lower than the CLP criteria at 500 and the PBT criteria
No harmonised classification is
available on the registered substance.
1 < lowest E(L)C50 value < 10 mg/L;
not readily biodegradable; experimental BCF = 14 - 56.
according to the Annex VI of the Regulation (EC) No 1272/2008 (CLP): The
registered substance is classified as Aquatic Chronic 2 for the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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