Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 245-844-2
CAS number: 23726-93-4
In an acute dermal toxicity study, groups of
CD® Sprague-Dawley outbred albino rats (5/sex/dose) were given single
dermal application of test material diluted in alcohol at 1670, 2150,
2780, 3600 and 4640 mg/kg bw at a constant volume of 6 mL/mg bw. Test
material was applied topically to the previously shaven dorsal area of
the animal and remained in contact for 24 h. A vehicle control group was
treated with undiluted alcohol in the same manner. Animals were then
observed for mortality, clinical signs and bodyweights for 14 days and
at the end of the study the surviving animals were sacrificed for
Range finding study was conducted at the
dose levels of 50, 160, 500, 1600 and 5000 mg/kg bw (2/sex/dose) to
determine the dose levels for main study. In the range-finding study, no
mortality or signs of compound induced toxicity were observed at 0, 50,
160 or 500 mg/kg bw. Mortality was observed in one male and two females
at 5000 mg/kg bw.
In the main study, no mortality was observed at
1670 or 2150 mg/kg bw. 3/10 (0 male + 3 females), 5/10 (0 male + 5
females) and 10/10 (5 males + 5 females) animals died at 2780, 3600 and
4640 mg/kg bw, respectively. Soft feces, mucous discharge or morbidity
were observed ante mortem in animals receiving 2780, 3600 or 4640 mg/kg
No mortality and no dermal irritation was
observed in the vehicle control animals.
Desquamation was observed between Days 7 and
14 in animals exposed to 1670, 2150, 2780 and 3600 mg/kg bw. The mean
body weight gain was slightly lower in males at 1670, 2150, 2780 and
3600 mg/kg bw and moderately lower in females at 2150 mg/kg bw when
compared to vehicle control. Mean body weight gains for the females
receiving 1670 and 2780 mg/kg bw were comparable to the controls. No
gross tissue alterations attributable to treatment were observed in any
of the animals.
Dermal LD50 Combined = 2900 mg/kg bw (95
% confidence limits of 2164-3886 mg/kg bw).
Under the test conditions, the test material
is not classified according to the annex VI of the Regulation EC No.
This study is acceptable and satisfies the
requirement for acute dermal toxicity endpoint.
The supporting substance is considered
adequate for read-across purpose (see Iuclid section 13 for
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again