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EC number: 245-844-2
CAS number: 23726-93-4
QSAR model, iSafeRat holistic approach v1.4, key study, validity 2:48h-EC50 = 9.0 mg/L (95% CL: 8.2 - 9.9 mg/L).
assess the toxicity of the registered substance to aquatic
invertebrates, one data point is available.
value (KREATiS, 2015), assessed as a key datapoint, is a QSAR. This QSAR
prediction (iSafeRat holistic approach v1.4) was performed on the
registered substance, to assess the acute
toxicity of the substance to daphnids. This
QSAR has been validated to be compliant with the OECD recommendations
for QSAR modelling (OECD, 2004) and predicts the endpoint value which
would be expected when testing the substance under experimental
conditions in a laboratory following OECD Guideline 202. The immobility
of the daphnids was determined using a validated QSAR for the Mode of
Action in question, (MOA 1, non-polar narcosis). Use of this MOA for
substituted α,β-unsaturated ketones has previously been demonstrated as
acceptable in a position paper (KREATiS, 2015; available in the Endpoint
Study Record). This QSAR is based on validated data for a training set
of 58 chemicals derived from 48-hour tests on daphnids, for which the
concentrations of the test substance had been determined by chemical
analyses over the test period. The water solubility of the
substance given as input was derived from the experimental log Kow
value, measured at 3.40 with a slow-stirring method. The substance falls
within the applicability domain of the model. The 48h-EC50 based
on mobility was determined to be 9.0 mg/L (95% CL: 8.2 - 9.9 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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