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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute dermal toxicity for CAS no: 68955-35-1
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017
Reference Type:
secondary source
Title:
IUCLID Dataset for CAS no: 68955-35-1
Author:
European Chemicals Bureau (ECB)
Year:
2000
Bibliographic source:
IUCLID Dataset, European Chemicals Bureau (ECB), 2000

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Acute dermal toxicity study of Naphtha (petroleum), catalytic reformed was performed in rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):Naphtha (petroleum), catalytic reformed
- Molecular formula :No data available
- Molecular weight :No data available
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):Naphtha (petroleum), catalytic reformed
- Molecular formula :No data available
- Molecular weight :No data available
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
2000mg/kg
No. of animals per sex per dose:
Total:8
Male:4
Female:4
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No Mortality was observed
Mortality:
No Mortality was observed
Clinical signs:
Moderate to severe skin irritation was observed.
Body weight:
No data available
Gross pathology:
Necroscopy revealed thickened and crusted skin on test areas and red focii on the cortex of one rabbit kidney.
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >2000mg/kg body weight. When rabbits were treated with Naphtha (petroleum), catalytic reformed (68955-35-1) by dermal application.
Executive summary:

Acute dermal toxicity study was done in 4 male and 4 female New Zealand White rabbits using test material Naphtha (petroleum), catalytic reformed (68955-35-1).The skin of two male and two female animals were abraded before application.No mortality observed at dose 2000mg/kg. Clinical signs like moderate to severe skin irritation were observed in treated rabbits.Necroscopy revealed thickened and crusted skin on test areas and red focii on the cortex of one rabbit kidney.Hence LD50 was considered to be > 2000mg/kg body weight. When rabbits were treated with Naphtha (petroleum), catalytic reformed (68955-35-1) by dermal application.