Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Cutaneous Toxicity
Author:
Drill, V.A., and P. Lazar,
Year:
1977
Bibliographic source:
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Data used from the following journal :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 . Volume(issue)/page/year: -,127,1977
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Name (IUPAC): 4-{bis[4-(dimethylamino)phenyl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium chloride
- Name of test material (as cited in study report): Gentian Violet
- Molecular formula: C25H30ClN3
- Molecular weight: 407.986 g/mol
- Smiles notation): CN(C)C1=CC=C(C=C1)C(=C2C=CC(=[N+](C)C)C=C2)C3=CC=C(C=C3)N(C)C.[Cl-]
- InChl : InChI=1S/C25H30N3.ClH/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6;/h7-18H,1-6H3;1H/q+1;/p-1
- Substance type: organic
- Physical state: Solid

Test animals

Species:
human

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified

Results and discussion

In vivo

Results
Time point:
other: 3D
Max. score:
3
Reversibility:
no data
Remarks on result:
other: Data used from journal available in public domin

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant)
Remarks:
Migrated information
Conclusions:
REACTION SEVERITY : Mild
Executive summary:

TYPE OF TEST: Standard Draize test

ROUTE OF EXPOSURE: Administration onto the skin

SPECIES OBSERVED: Human

DOSE/DURATION: 3mg/3D (Intermittent)

REACTION SEVERITY:Mild