Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-057-0
CAS number: 36483-57-5
see attached document on tables
Acute oral toxicity with FR-513 in the rat was carried out using
appropriate guidelines of OECD 423, OPPTS 870.1100.
FR-513 was administered by oral gavage to two subsequent groups of three
female Wistar rats at 2000 mg/kg body weight.
Animals were subjected to daily observations and weekly determination of
body weight. Macroscopic examination was performed after terminal
sacrifice (day 15). The incidance of mortality was 1/3 based on two
observations. Lethargy, restless behaviour, hunched posture,
ventro-lateral recumbency, flat gait, uncoordinated movements, laboured
respiration, piloerection, salivation, ptosis, squeaking, and/or
hypothermia were noted among animals between days 1 and 3. The body
weight was considered normal and no abnormalities were found at
macroscopic post mortem examination of the animals. The oral LD50 value
of FR-513 in Wistar rats was established to exceed 2000 mg/kg body weight
According to the OECD 423 test guideline the LD50 cut-off value was
considered to be 2500 mg/kg body weight.
Based on the results FR-513 is considered not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again