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EC number: 253-057-0
CAS number: 36483-57-5
see attached document on tables
Evaluation of the ability of FR-513 to induce chromosome aberrations in
cultured peripheral human lymphocytes was conducted using appropriate
guidelines such as OECD 473. The report describes the effect of FR-513
on the number of chromosome aberrations in cultures perpheral human
lymphocytes in the presence and absence of a metabolic activation
system. A range finder study was conducted which followed by several
It is concluded that the test was valid and under the experimental
conditions FR-513 was found to be clastogenic in the presence of
metabolic activation and at the highest test substance concentration
(1000 microgram/ml) in the absence of metabolic activation. FR-513 has
the potential to disturb mitotic processes and cell cycle progression.
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