Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-057-0
CAS number: 36483-57-5
see attached document on tables
Evaluation of the ability of FR-513 to induce chromosome aberrations in
cultured peripheral human lymphocytes was conducted using appropriate
guidelines such as OECD 473. The report describes the effect of FR-513
on the number of chromosome aberrations in cultures perpheral human
lymphocytes in the presence and absence of a metabolic activation
system. A range finder study was conducted which followed by several
It is concluded that the test was valid and under the experimental
conditions FR-513 was found to be clastogenic in the presence of
metabolic activation and at the highest test substance concentration
(1000 microgram/ml) in the absence of metabolic activation. FR-513 has
the potential to disturb mitotic processes and cell cycle progression.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again