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EC number: 253-057-0
CAS number: 36483-57-5
see attached document on tables
Acute dermal toxicity was conducted with FR-513 in the rat according to
various OECD guidelines such as OECD 402 and OPPTS 870.1200. FR-513 was
administered to five Wistar rats of each sex by dermal application at
2000 mg/kg body weight for 24 hr. Animals were subjected to daily
observations and weekly determination of body weight. Macroscopic
examination was performed after terminal sacrifice (day 15). No
mortality occured. Lethargy, flat posture, hunched posture,
piloerection, ptosis, red urine, chromodacryorrhoea and/or shallow
respiration were noted among the animals. The animals had recovered from
the symptoms by day 5.
General or maculate erythema, necrosis, scales, scars and/or scabs were
seen in the treated skin-area of the animals during the observation
The mean body weight gain during the observation period was within the
range expected for rats used in this type of study.
Macroscopic post mortem did not reveal any abnormalities that were not
commonly noted among rats of this age and strain.
The dermal LD50 value FR-513 in Wistar rats was established to exceed
2000 mg/kg body weight, hence considered non classified in the EU.
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