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Physical & Chemical properties

Dissociation constant

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Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data reported in the Hazardous Substances Data Bank. The test material is not identical to registration substance, but is a constituent of the registration substance.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data reported in the Hazardous Substances Data Bank
GLP compliance:
no
Specific details on test material used for the study:
The registration substance is a mixture (UVCB). Different components of a mixture may have different pKa values. Therefore the data is given for constituent of the registration substance:
2,4-xylenol
Dissociating properties:
yes
No.:
#1
pKa:
10.6
Temp.:
25 °C
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data reported in Hazardous Substances Data Bank. The test material is not identical to registration substance, but is a constituent of the registration substance.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data reported in Hazardous Substances Data Bank
GLP compliance:
no
Specific details on test material used for the study:
The registration substance is a mixture (UVCB). Different components of a mixture may have different pKa values. Therefore the data is given for constituent of the registration substance:
3,5-xylenol
Dissociating properties:
yes
No.:
#1
pKa:
10.19
Temp.:
25 °C
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data reported on the Hazardous Substances Data Bank. The test material is not identical to registration substance, but is a constituent of the registration substance.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data published in the Hazardous Substances Data Bank
GLP compliance:
no
Specific details on test material used for the study:
The registration substance is a mixture (UVCB). Different components of a mixture may have different pKa values. Therefore the data is given for constituent of the registration substance:
2,5-xylenol
Dissociating properties:
yes
No.:
#1
pKa:
10.41
Temp.:
25 °C
No.:
#1
pKa:
10.3
Remarks on result:
other: temperature not reported

Temperature is not reported in the Blackman Article

Description of key information

pKa: 10.2 - 10.6 at 25 °C

Values of individual constituents:

2,4-xylenol: 10.6 at 25 °C

2,5-xylenol: 10.4 at 25 °C

3,5-xylenol: 10.2 at 25 °C

Key value for chemical safety assessment

Additional information

The reported values for the dissociation constants of the main constituents of Tar acids, xylenol fraction range from pKa values of 10.19 -10.6