Registration Dossier
Registration Dossier
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EC number: 701-325-7 | CAS number: -
Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
The test substance is a watery solution of metal chlorides and free hydrogenchloride.
The toxicity of this mixture has therefore to be regarded as a summary of the toxicity of the different ingredients. Due to the relative concentrations for neurotoxicity FeCl2, MnCl2, AlCl3 and HCl are regarded. MgCl2 the only other substance of high concentration is disregarded due to the low overall toxicity of this substance and as both chloride and magnesium ions are essential for cellular life and present in every cell in high abundance.
FeCl2:
No data is available.
MnCl2:
Due to a delay in the correspondance between the registrant of this test substance and the Manganese Consortium, no first hand animal data is available.
Secondary data from the ACGIH document "Manganese, Elemental and Inorganic Compounds: TLV® Chemical Substances Draft Documentation, Notice of Intended Change" reports a TLV–TWA of 0.02 mg Mn/m³ for respirable particulate matter and a TLV–TWA of 0.2 mg Mn/m 3 for inhalable particulate matter (= 0.0458 and 0.458 mg MnCl2/m3).
Critical endpoints are preclinical, adverse, neurophysiological, and neuropsychological effects.
AlCl3:
A study using aluminium citrate was conducted to analyse the effect of aluminium on neurotoxicity in the offspring after oral dosing in a developmental neurotoxicity study (Semple 2010 in chapter). A NOAEL of 30 mg/Kg bw Al(III) was determined based on effects in fore- and hind-limb grip strength and other parameters. In addition a delayed sexual maturation was seen in the high dose animals, but as a comparable effect was seen in the sodium citrate control group, this effect cannot be clearly assigned to Al(III). Generally these findings are of less relevance as the complexation with citrate increases the aluminium uptake drastically as compared to aluminium chloride.
HCl:
No data is available.
Justification for classification or non-classification
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