Registration Dossier
Registration Dossier
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EC number: 701-325-7 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No meaningful threshold levels can be identified and no toxicity is assumed for iron and aluminium. Manganese effects were assessed by SSD.
Key value for chemical safety assessment
Additional information
Iron
No valid and conclusive studies are available or can be made under laboratory conditions (see discussion on Aquatic toxicity). It is concluded that acute and chronic aquatic toxicity testing with the submission item or Fe(II) salts in general is under aerobic conditions technically not feasible and scientifically unjustified. Up to the level of its water solubility, which is almost identical to the natural background concentrations no toxicity is assumed.
Thus the threshold levels for the submission item need to derived from effects of the remaining relevant major components, aluminium and manganese.
Manganese
No long-term threshold levels are available in the literature. The hazard to the aquatic life is assessed on the basis of a Species Sensitivity Distribution (SSD) calculation (see discussion on Aquatic toxicity).
Aluminium
The lowest long-term threshold level was measured in a 60 d early-life-stage fish (Salvelinus fontinalis) toxicity study. The experiment revealed a NOEC of 13 µg dissolved Al/L (Ceveland et al 1989) based on incomplete hatching. It was a semi-static test at a pH of 6.5-6.6.
Nonetheless the study is valid and conclusive it does not reflect the natural situation and can not be used of the chemical safety assessment. Firstly it is to remark that the NOEC ranges below the environmental background concentrations. Secondly the aluminium concentration in the environment is generally at the maximum of its solubility under the particular environmental conditions of the respective location. In consequence large variations are observed and it is considered likely that adaptation to the local aluminium levels is an important factor in aquatic biota. It is suggested that the reduced hatching success in the study of Cleveland et al (1989) represents a passing effect of selection and would disappear in the following generation(s). For details see discussion on ecotoxicological information / conclusion on the environmental hazard assessment.
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