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EC number: 205-381-9
CAS number: 139-89-9
Skin - Slightly irritating
Eye - Highly irritating
using non-standard methods with HEDTA-Na3 and in vitro studies with
HEDTA-H3 indicate that prolonged or repeated contact, particularly on
abraded skin, may result in moderate irritation and burn. Short-term
contact of a few minutes to hours may cause little or no apparent
effects. Three studies describe corrosivity testing to US DOT standards
with a 4 hour exposure, the same exposure period as used by OECD/EU test
methods. HEDTA-Na3 was mixed with varying concentrations of NaOH and, at
low NaOH concentration, no corrosion was noted. EDTA-Na4, a structural
analogue of HEDTA-Na3, was not significantly irritating to the skin when
assessed using standard methods. The same is expected of HEDTA.
Eye irritation has been carried out with
HEDTA-Na3 and HEDTA-H3 ex-vivo with the results indicating the potential
for the undiluted substance to cause severe eye irritation, as was also
seen with EDTA-Na4. This is supported by a number of in-vivo studies
with HEDTA-Na3 for the assessment of eye irritation, most of which are
poorly documented. The best documented (Dow, 1982) describes a single
exposure of one animal to HEDTA + 1.9% NaOH. Results indicated marked
discomfort, moderate conjunctival redness and swelling, reddening of the
iris and moderate corneal cloudiness. Signs of irritation were present
at 21 days if not washed. The effects were considered fully reversible
on washing out within 30 seconds. The extent of the influence of NaOH on
the observed irritation is not clear. Five additional, poorly
documented, studies on exposure to HEDTA-Na3 products are available and
indicate that exposure may cause slight to moderate eye irritation in
rabbits. The information from these studies is regarded as sufficient to
be able to draw conclusions regarding the need for classification and
the results of the available data the substance does not require to be
classified and labelled according to Regulation 1272/2008/EC (CLP).
information available is regarded as sufficient to be able to draw
conclusions regarding the need for classification.
of the undiluted substance as “causes serious eye damage” Category 1 -
H318 according to CLP (1272/2008/EC) is indicated.
solution at a concentration of 40% or less, a reduced classification of
“causes serious eye irritation” – Category 2 - H319 according to CLP
(1272/2008/EC) is indicated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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