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EC number: 205-381-9
CAS number: 139-89-9
It is considered likely that HEDTA will
behave similarly to EDTA. It is expected to poorly absorb across the
gastrointestinal tract and will be excreted rapidly and largely
unchanged. Dermal absorption is expected to be minimal.
is limited information available on the toxicokinetics of HEDTA. The
mode of action of this type of substance is thought to be due to its
chelating capabilities. A higher chelating potential (and a large size)
will reduce the potential for the substance to move across membranes and
therefore reduce absorption and bioavailability. A review of the binding
and ionisation potential of HEDTA and its structural analogue, EDTA,
indicates that the behaviour of both is similar (Dwibedyet al.,
1999). The rate constants for the reaction of both chemicals with OH
radicals indicate an increase with increase in pH, with an opposite
trend observed in a small mid-region of pH (between 1 and 3).
are no studies on the absorption, metabolism, distribution or
elimination (ADME) of HEDTA. Toxicokinetic studies in humans and rats
indicate that the structural analogue, EDTA, is poorly absorbed across
the gastrointestinal tract. The absorbed EDTA did not undergo any
biotransformation and was rapidly excreted unchanged in urine. However
it was noted that there as an increase in excretion of necessary ions
such as Zn, Mn or Ca. It is considered likely that HEDTA will behave
similarly to EDTA and on this basis it is expected to poorly absorb
across the gastrointestinal tract and will be excreted rapidly and
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