Registration Dossier
Registration Dossier
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EC number: 205-381-9 | CAS number: 139-89-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary information only, very limited information is available for the interpretation of the results.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- This study followed internal Dow procedures.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate)
- EC Number:
- 205-381-9
- EC Name:
- Trisodium 2-(carboxylatomethyl(2-hydroxyethyl)amino)ethyliminodi(acetate)
- Cas Number:
- 139-89-9
- Molecular formula:
- C10H18N2O7.3Na
- IUPAC Name:
- trisodium [{2-[bis(carboxylatomethyl)amino]ethyl}(2-hydroxyethyl)amino]acetate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): N-hydroxyethyl ethylenediamine triacetic acid, trisodium salt (Versene powder)
- Molecular formula (if other than submission substance): C10H15O7N2Na3
- Molecular weight (if other than submission substance): 344.20
- Physical state: powder
- Color: White
- All other template details: Not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not reported
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Not reported
- Duration of exposure:
- undiluted - intact skin - 10 applications to the belly
undiluted -abraded skin - 3 applications to the belly
10% aqueous solution - intact skin - 10 applications to the ear
10% aqueous solution - intact skin - 10 applications to the belly
10% aqueous solution - abraded skin - 3 applications to the belly - Doses:
- undiluted and in a 10% aqueous solution
- No. of animals per sex per dose:
- Not reported
- Control animals:
- no
- Details on study design:
- - Conclusions based on the skin irritation/corrosion study
- Duration of observation period following administration: up to 21 days
- All other template details: not reported - Statistics:
- Not reported
Results and discussion
- Preliminary study:
- There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
- Mortality:
- None reported
- Clinical signs:
- other: undiluted - intact skin - 10 applications to the belly: Slight hyperemia throughout experiment - slight edema persisted after 4th application. undiluted -abraded skin - 3 applications to the belly: Slight to moderate hyperemia with slight edema after each
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Conclusions:
- There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
- Executive summary:
There is no indication from the skin irritation tests conducted that this material is absorbed through the skin in toxic amounts.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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