Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-046-0 | CAS number: 65997-17-3 This category encompasses the various chemical substances manufactured in the production of inorganic glasses. For purposes of this category, 'glass' is defined as an amorfous, inorganic, transparent, translucent or opaque material traditionally formed by fusion of sources of silica with a flux, such as an alkali-metal carbonate, boron oxide, etc. and a stabilizer, into a mass which is cooled to a rigid condition without crystallization in the case of transparent or liquid-phase separated glass or with controlled crystallization in the case of glass-ceramics. The category consists of the various chemical substances, other than by-products or impurities, which are formed during the production of various glasses and concurrently incorporated into a glass mixture. All glasses contain one or more of these substances, but few, if any, contain all of them. The elements listed below are principally present as components of oxide systems but some may also be present as halides or chalcogenides, in multiple oxidation states, or in more complex compounds. Trace amounts of other oxides or chemical compounds may be present. Oxides of the first seven elements listed* comprise more than 95 percent, by weight, of the glass produced. @Aluminium*@Lead@Boron*@Lithium@Calcium*@Manganese@Magnesium*@Molybdenum@Potassium*@Neodymium@Silicon*@Nickel@Sodium*@Niobium@Antimony@Nitrogen@Arsenic@Phosphorus@Barium@Praseodymium@Bismuth@Rubidium@Cadmium@Selenium@Carbon@Silver@Cerium@Strontium@Cesium@Sulfur@Chromium@Tellurium@Cobalt@Tin@Copper@Titanium@Germanium@Tungsten@Gold@Uranium@Holmium@Vanadium@Iron@Zinc@Lanthanum@Zirconium
Carcinogenicity
Administrative data
Description of key information
The carcinogenic potential of E-glass microfibre has been tested experimentally in two chronic toxicity inhalation studies in rats. In both studies E-glass microfibre was found to be tumourigenic at high exposure concentrations. E-glass microfibre induced carcinomas, adenomas and mesotheliomas as well as severe fibrosis in the lungs of male rats exposed by inhalation to E-glass microfibre for 12 months (7 h/day, 5 days/week for 12 months).
E-glass microfibre is proposed to be classified Carc. Cat. 2; R49: May cause cancer by inhalation.
Key value for chemical safety assessment
Justification for classification or non-classification
Proposed classification by the registrant is Carc. Cat. 2; R49: May cause cancer by inhalation.
Additional information
The potential of E-glass micofibre (i.e. code 104E fibres) to induce lung fibrosis and cancer/neoplastic changes was investigated experimentally by long-term whole body exposure of male rats to inhalation of aerosols of E-glass microfibre (1000 WHO fibres/ml) for 7 hours a day, 5 days a week and up to 12 months, followed by a recovery period of up to 12 months (Searl et al 1999; Cullen et al 2000).
The methods used in the studies were similar to those described in EC guideline (ECB/TM/17(97) rev. 2) with some deviations.
The studies showed that E-glass microfibre induced fibrosis, carcinomas, adenomas and mesotheliomas in the rat. It is noted that an ILSI working group recently stated (ILSI, 2005) that all fibres that have caused cancer in animals via inhalation have also caused fibrosis at an earlier time point, that is after 3-month exposure. However, there have been fibres that have caused fibrosis but not cancer.Carcinogenicity: via inhalation route (target organ): respiratory: lung
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
