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EC number: 284-895-5
CAS number: 84989-06-0
The fraction of tar acids, rich in 2,4- and 2,5-dimethylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
To determine LD-50 value, rabbits received
dermal application of 215 - 681 mg/kg bw undiluted p-cresol and were
observed for sclinical signs of toxicity and mortality for up to 14
days: LD50 was determined to be 301 mg/kg bw. As signs of intoxication
tremor, salivation, sedation were noted; the treated skin showed severe
erythema and severe subdermal hemorrhaging.
Table 1: Mortality and clinical symptoms
onset of sympt
S = signs of
intoxication from 4 hrs up to 12 hrs p.a.:
salivation, hypersensitivity, convulsion, hypoactivity;
dermal irritation: severely burned, severe oedema; gross
necropsy-survivors: no significant finding, gross necropsy-decedents:
hyperemia of lungs and kidneys
Application of test substance to the skin of
rabbits and an exposure observation time for 14 days yielded a LD50 of
2050 mg/kg bw and severe irritational effects.
No clinical signs of toxicity reported up to
Dermal application of the testsubstance to
the skin of rabbits resulted in a LD50 value of 1380 mg/kg bw
(Industrial Biotest Laboratories 1969).
In the result table above the most critical value of the weight of
evidence approach is given. In the following, the results are shown for
the other source substances of this weight of evidence approach:
Source CAS 95 -48 -7: o-cresol: LD50 (sex unspecified, rabbit) = 1380
mg/kg bw (95% CL: >= 841 <= 2260); IBTL, 1969
Source CAS 108 -39 -4: m-cresol: LD50 (sex not specified, rabbit) > 2050
mg/kg bw; IBTL, 1969
Source CAS 108 -68 -9: 3,5-xylenols: LD50 (male/female, rat) >2400 mg/kg
bw; Rütgers, 1981
The acute dermal toxicty study on 3,5-xylenol resulted in a LD50 of >
2400 mg/kg bw for male and female rats. For the three cresol isomers the
LD50 values were between 301 and 2050 mg/kg bw for rabbits. Thus, the
cresol isomers seem to have a more toxic potential regarding acute
dermal toxicity than 3,5-xylenol. However, as there are no acute dermal
toxicity data available for Tar acids, Xylenol fraction (CAS 84989-06-0)
a worst-case approach was conducted taking into account all available
data on the source substances and Tar acids, Xylenol fraction (CAS
84989-06-0) was therefore classified in Cat. 3 (H311) for acute dermal
toxicity according to Regulation (EC) No 1272/2008.
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