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EC number: 284-895-5
CAS number: 84989-06-0
The fraction of tar acids, rich in 2,4- and 2,5-dimethylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
- Only the nominal value for the most sensitive parameter is
given. However, no losses were reported to be greater than 20%.
- Tested concentration range: 0.003-10 mg/L
The long-term toxicity of p-cresol to aquatic invertebrates was
determined by a test according to the preliminary guideline proposal of
the German Umweltbundesamt from1984. The 21d-NOEC is 1 mg/L.
LC50 = 11.08 mg/l after 10 days
LC10 = 2.0 mg/l after 80 days (4 generations)
LC20 = 4.0 mg/l after 80 days (4 generations)
In a non-guideline study with a 4 generations of the planarian Dugesia
tigrina, an 80 d-EC10 of 2 mg/L was measured.
Based on all available information (weight-of-evidence and following an
analogue read-across and worst case approach the freshwater NOEC (21d)
of 1.0 mg/L determined for Daphnia magna (Kühn et al., 1988; Kühn, 1989)
for p-cresol represents the most sensitive effect value for chronic
toxicity to aquatic invertebrates for Tar acids, Xylenol fraction (CAS
84989-06-0) and is considered as key value for the chemical safety
Data on the chronic toxicity to aquatic invertebrates are available for
constituents of Tar acids, Xylenol fraction (CAS 84989-06-0), i.e.
p-cresol and 2,4-xylenol. These data are used to determine the hazard of
Tar acids, Xylenol fraction (CAS 84989-06-0) by applying a weight of
evidence and an analogue read-across approach. The studies were
conducted with different species of freshwater invertebrates. A
worst-case scenario is followed, i.e. for classification and assessment
purposes the most sensitive values are considered. Although only data
for p-cresol and 2,4-xylenol are available it is emphasized here, that
there is numerous data available for several different constituents for
acute and chronic toxicity to fish and acute toxicity to aquatic
invertebrates. These data exemplify that effect values are in general in
the same order of magnitude and effect values for p-cresol in particular
are among the lowest. Therefore, data presented here for chronic aquatic
toxicity to invertebrates are considered to be representative for Tar
acids, Xylenol fraction (CAS 84989-06-0). For details on the read-across
approach please refer to the analogue justification provided in IUCLID
Chronic effect values determined in the studies available are listed in
the table below:
Solski & Piontek, 1987
EC10 (80d) = 2.0 mg/L
Kuehn et al., 1988-1989
NOEC (21d) = 1.0 mg/L
Snell & Moffat, 1992
NOEC (24h) = 2.0 mg/L
* f = freshwater
From the table above it can be seen that available data demonstrate
effect values for chronic toxicity to aquatic invertebrates in a close
range from 1.0 to 2.0 mg/L. The most sensitive value for freshwater
(Daphnia magna) was determined in the study by Kühn et al. (1988) and
Kühn (1989) with a NOEC (21d) of 1.0 mg/L for p-cresol. This value is
considered for PNEC derivation and risk assessment and for deriving
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