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EC number: 284-895-5 | CAS number: 84989-06-0 The fraction of tar acids, rich in 2,4- and 2,5-dimethylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Remarks:
- 42 days
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- refer to analogue justification provided in IUCLID section 13
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- short-term repeated dose toxicity: dermal
- Remarks:
- 42 days
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: special study and only one dose used, no dose-response relationship can be derived and thus no NOAEL or LOAEL can be deduced.
- Principles of method if other than guideline:
- Hair pigmentation was studied following plucking or clipping the caudal half of the back and repeated application of laundry ink or its pure component chemicals incl. p-cresol in a concentration of 0.5% in acetone. p-Cresol was applied to the skin of 30 males. Hair colour was observed weekly for the subsequent 6 months. Microscopic examinations of post-treatment hairs and skin biopsies of areas of non-pigmented and normally pigmented hair were made. Control groups of animals received acetone.
- GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- C57BL
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- not specified
- Vehicle:
- acetone
- Details on exposure:
- no data
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- 3x/week
- Dose / conc.:
- 0.5 other: % in acetone
- No. of animals per sex per dose:
- 30 male animals
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: 6 months
- Positive control:
- no data
- Observations and examinations performed and frequency:
- Hair colour was observed weekly for the subsequent 6 months. Microscopic examinations of post-treatment hairs and skin biopsies of areas of non-pigmented and normally pigmented hair were made
- Sacrifice and pathology:
- no data
- Other examinations:
- no data
- Statistics:
- no data
- Details on results:
- Topical application caused depigmentation of the hair and pigmented epidermis, especially of the tail. Large amounts of p-cresol were lethal and had a local caustic erosive effect.
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- < 0.5 other: %
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: depigmentation of the hair and pigmented epidermis, especially of the tail; large amounts of p-cresol were lethal and had a local caustic erosive effect
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- <= 0.5 other: %
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: depigmentation of the hair and pigmented epidermis, especially of the tail; large amounts of p-cresol were lethal and had a local caustic erosive effect
- Critical effects observed:
- not specified
- Conclusions:
- p-Cresol was applied to the skin of 30 males. Hair colour was observed weekly for the subsequent 6 months. Microscopic examinations of post-treatment hairs and skin biopsies of areas of non-pigmented and normally pigmented hair were made. Control groups of animals received acetone. Topical application caused depigmentation of the hair and pigmented epidermis, especially of the tail. Large amounts of p-cresol were lethal and had a local caustic erosive effect.
Data source
Materials and methods
Test material
- Reference substance name:
- Tar acids, xylenol fraction
- EC Number:
- 284-895-5
- EC Name:
- Tar acids, xylenol fraction
- Cas Number:
- 84989-06-0
- Molecular formula:
- not applicable
- IUPAC Name:
- 2,3-dimethylphenol; 2,4-dimethylphenol; 2,5-dimethylphenol; 2,6-dimethylphenol; 3,4-dimethylphenol; 3,5-dimethylphenol
Constituent 1
Results and discussion
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Remarks:
- mouse
- Effect level:
- < 0.5 other: %
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: depigmentation of the hair and pigmented epidermis, especially of the tail; large amounts of p-cresol were lethal and had a local caustic erosive effect
- Remarks on result:
- other: Source, CAS 106-44-5, p-cresol, Shelly, 1974
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- <= 0.5 other: %
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: depigmentation of the hair and pigmented epidermis, especially of the tail; large amounts of p-cresol were lethal and had a local caustic erosive effect
- Remarks on result:
- other: Source, CAS 106-44-5, p-cresol, Shelly, 1974
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The available data is not reliable for hazard assessment of Tar acids, Xylenol fraction (CAS 84989-06-0). Further testing is, however, not required, as there are reliable oral repeated dose toxicity data available for the hazard assessment of Tar acids, Xylenol fraction (CAS 84989-06-0) and therefore, the requirements defined in Regulation (EC) No 1907/2006, Annex IX, 8.6 are fulfilled.
- Executive summary:
p-Cresol was applied to the skin of 30 males. Hair colour was observed weekly for the subsequent 6 months. Microscopic examinations of post-treatment hairs and skin biopsies of areas of non-pigmented and normally pigmented hair were made. Control groups of animals received acetone. Topical application caused depigmentation of the hair and pigmented epidermis, especially of the tail. Large amounts of p-cresol were lethal and had a local caustic erosive effect.
The available data is not reliable for hazard assessment of Tar acids, Xylenol fraction (CAS 84989-06-0). Further testing is, however, not required, as there are reliable oral repeated dose toxicity data available for the hazard assessment of Tar acids, Xylenol fraction (CAS 84989-06-0) and therefore, the requirements defined in Regulation (EC) No 1907/2006, Annex IX, 8.6 are fulfilled.
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