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EC number: 284-895-5
CAS number: 84989-06-0
The fraction of tar acids, rich in 2,4- and 2,5-dimethylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
The A/D ratio (the dose level at which
there were no observable effects in offsprings) is less than 1: (30/175)
indicating no increased risk to offspring from o-cresol in the absence
of parental effects.
For the three cresol isomers two-generation studies in rats showed that
the general toxicity was dominating over the reproductive toxicity as a
NOAEL of 30 mg/kg bw/day for general toxicity was derived. No
reproductive parameters were affected by the treatment in either of the
two generations resulting in a NOAEL of 450 mg/kg bw/day for fertility.
The offsprings (F1 and F2) showed toxic effects mainly regarding
clinical signs, body weight and lacation index leading to a NOAEL of 175
mg/kg bw/day. Whilst no studies on toxicity to reproduction have been
conducted with xylenols or ethylphenols, the experimental data available
on cresols are considered to be suitable and meaningful to predict
toxicity to reproduction (fertility) of the target substance.
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