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EC number: 284-895-5
CAS number: 84989-06-0
The fraction of tar acids, rich in 2,4- and 2,5-dimethylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
Following exposure of rats against 0.71 mg/L
p-cresol for 1 hour, no rat died and no clinical findings were reported.
No mortality occurred following the exposure
of 6 rats to 0.71 mg/L for 1 hr and within the 14 day observation
period. Clinical signs or findings following sacrifice were not reported.
In rats, the LC50 value of 58 mg/m³ resulted
from exposure against m-cresol aerosols (exposure time not mentioned).
Clinical signs reported included irritation of the mucous membranes,
neuromuscular excitation and convulsions.
no further details
Exposure of male rats to the test substance
for 1 hour and postexposure observation for clinical signs and mortality
resulted in no mortality, but generalized inactivity: LC50 > 1.22
In the result table above the most critical value of the weight of
evidence approach is given. In the following, the results are shown for
the other source substances of this weight of evidence approach:
Source CAS 106 -44 -5: p-cresol: LC50 (male, rat) > 0.71 mg/L air (1 h
exposure duration); IBTL, 1969
Source CAS 108 -39 -4: m-cresol: LC50 (male, rat) > 0.71 mg/L air (1 h
exposure duration); IBTL, 1969
Source CAS 108 -39 -4: m-cresol: LC50 (sex not specified, rat) 58.0
mg/m³ air (exposure duration not specified); Pereima, 1975
Source CAS 108 -68 -9: 3,5 -xylenols: LC50 (male/female, rat) > 0.07
mg/L air; (7 h exposure duration), estimated air concentration (as gas)
base on saturation (~ 1.3 mg/L), assuming 50% air saturation under test
conditions; (Rütgers, 1981)
Studies on cresol isomers and 3,5-xylenol are available, but the quality
of the data does not allow a final conclusion on acute inhalation
toxicity. Further testing is, however, not required, because Tar acids,
Xylenol fraction (CAS 84989-06-0) is evaluated as corrosive in a
worst-case approach and classified / labelled accordingly. This is in
accordance with the specific rules (Column 2) of Annex VIII No. 8.5 of
Regulation (EC) No. 1907/2006 (REACH): acute toxicity studies do not
generally need to be conducted if the substance is classified as
corrosive to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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