1,4-bis(2,3-epoxypropoxy)butane

Adsorption / desorption

Description of key information

The adsorption coefficient for both soil and sewage sludge was determined based on the retention times of the active ingredient (ca. 2.03 minutes), the lower limit of the peak (ca. 1.91 minutes), and the upper limit of the peak (ca. 2.64 minutes) using OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC).

The adsorption coefficient of the test substance on soil is estimated as log Koc of 1.1 ±0.7 (pH = 6.7, 25 °C) with a lower limit of 0.6 ±0.8 and an upper limit of 3.0 ±0.5 (pH 6.7, 25 °C). 

The adsorption coefficient of the test substance on sewage sludge is estimated as log Koc of 1.3 ±0.9 (pH = 6.7, 25 °C) with a lower limit of 0.8 ±1.0 and an upper limit of 3.3 ±0.7. In general substances with a Koc <500 – 1000 L/kg are not likely sorbed to sediment (SETAC 1993). According to this, a log Koc or log Kow of ≥3 is used as a trigger value for sediment effects assessment. On this basis, the substance is expected to demonstrate high mobility in soil and medium to high mobility in sewage sludge. SETAC. 1993. Guidance Document on Sediment Toxicity Tests and Bioassays for Freshwater and Marine Environments. From the Workshop on Sediment Toxicity Assessment at Renesse, Netherlands on 8-10 November 1993. Hill I, Mathiessen P, Heimbach F (eds). Society of Environmental Toxicology and Chemistry – Europe, Brussels.

Key value for chemical safety assessment

Koc at 20 °C:

20

Additional information

The key study is a Klimisch-1, GLP-compliant study, sponsored by the Epoxy Resin Consortium and carried out in 2010 by the Výzkumný ústav organických syntéz a.s. (Čížek K) according to OECD 121 and EU Method C.19 (HPLC estimation method). The adsorption coefficient of the substance in soil and in sewage sludge was estimated by comparison of the substance’s retention time compared to the retention times of six reference compounds (acetanilide (CAS 103-84-4), benzamide (CAS 55-21-0), 2,5-dichloroaniline (CAS 95-82-9), phenyl benzoate (CAS 93-99-2), phenanthrene (CAS 85-01-8), and fenthion (CAS 55-38-9)).

As the test substance produced a wide uneven peak, the adsorption coefficient for both soil and sewage sludge was determined based on the retention times of the active ingredient (ca. 2.03 minutes), the lower limit of the peak (ca. 1.91 minutes), and the upper limit of the peak (ca. 2.64 minutes). The adsorption coefficient of the test substance on soil is estimated as log Koc of 1.1 ±0.7 (pH = 6.7, 25 °C) with a lower limit of 0.6 ±0.8 and an upper limit of 3.0 ±0.5. The adsorption coefficient of the test substance on sewage sludge is estimated as log Koc of 1.3 ±0.9 (pH = 6.7, 25 °C) with a lower limit of 0.8 ±1.0 and an upper limit of 3.3 ±0.7.

Since both log Koc (soil) and log Koc (sludge) are below the lower limit of the method (lower limit = 1.5 log units), the results are considered less reliable.