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Physical & Chemical properties

Vapour pressure

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Description of key information

Vapour pressure (OECD Guideline n. 104) = 0.25 Pa at 25 °C

Key value for chemical safety assessment

Vapour pressure:
0.25 Pa
at the temperature of:
25 °C

Additional information

The key study for vapour pressure is a Klimisch-1 effusion method. The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures with linear regression analysis and repeated four times in four independent experiments. The results of all the experiments are in very good agreement with each other leading to a very similar output.


The study by Paulus (2010) overall is a Klimisch-3 because of a significant methodological deficiency. However, the initial stage of the Paulus study deserves a Klimisch rating of 1. The experimental flaw of the study was that all experiments had been performed with the same sample which was chemically instable during the experiment. In effect, the substance gradually polymerized during the experiment which reduced the apparent vapour pressure. However, the result at 30 °C is in good agreement with the Harlan study: after >2 days at 10^-8 Pa no significant weight loss was observed. This is consistent with a vapour pressure of <1 Pa at 30 °C.  

The study by Lasry (2010) is a Klimish-3 disregarded study because significant deficiencies in sample preparation compromised the outcome of the study. The sample had neither been dried nor was stored over silica gel before the study, causing the sample to attract humidity during storage. This humidity distilled off during the initial evacuation of the sample leading to the formation of bubbles which were wrongly attributed to a low boiling ingredient of the substance.