Registration Dossier
Registration Dossier
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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study obtained through inquiry process. SNIF file obtained from ECHA.
Data source
Reference
- Reference Type:
- other: SNIF
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- EC Number:
- 415-430-8
- EC Name:
- A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- Cas Number:
- 86403-32-9
- Molecular formula:
- C25H49NO2 and C27H53NO2
- IUPAC Name:
- Reaction mass of 2,2,6,6-tetramethylpiperidin-4-yl hexadecanoate and 2,2,6,6-tetramethylpiperidin-4-yl octadecanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Fur was clipped, skin was unabraded
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- olive oil
- Duration of exposure:
- 24 h
- No. of animals per sex per dose:
- 5
- Details on study design:
- Animals were observed for 14 days after exposure. Additional data is forthcoming.
- Statistics:
- Additional data is forthcoming.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No information from migrated NONS file
- Mortality:
- Male: 5000 mg/kg bw:, Number of animals: 5; Number of deaths: 0.
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0. - Clinical signs:
- other: Signs of toxicity related to dose levels: No effects.
- Gross pathology:
- Effects on organs: No effects.
- Other findings:
- Signs of toxicity (local): No effects.
Any other information on results incl. tables
Additional data is forthcoming.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was tested in an OECD-compliant acute dermal toxicity test in rats. No deaths occurred at doses up to 5,000 mg/kg bw in contact with the clipped skin of rats for 24 hours.
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