Registration Dossier

Administrative data

Description of key information

VCl3 is very hygroscopic and gives, in contact of humidity :

VCl3 + H2O => VOCl + 2 HCL

VOCl + 1/2Cl2 => VOCl2

The dissolution reaction in water is instantaneous (half-life of VCl3 < 1 hour – VCl3 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.

Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl3 is considered as corrosive.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Justification for classification or non-classification

With the physico-chemical property (HCl generation) and the weight of evidence (industrial practise), VCl3 is considered as corrosive on the criteria basis of the CLP regulation.

It is not possible to assign a sub-category (1A, 1B, 1C) on basis on physico-chemical effects (guidance on the application of the CLP criteria, version 5.0, July 2017).

Thereover, these corrosive sub-categories apply to some authorities and in transport, assigning or changing the packing group is particularly significant as it determines the requirements for the containment system and downstream consequences relating to the transport operation. The relationship between ADR (Agreement on Dangerous goods by Road) classification and GHS corrosive classification has been evaluated by the Committee of Experts on the Transport of Dangerous Goods and on the Globally Harmonized System of classification and Labelling of Chemicals, on 2012 and 2013 (ref. UN/SCETDG/41/ INF.53, UN/SCEGHS/23/INF.18, ST/SG/AC.10/C.3/2013/68 and ST/SG/AC.10/C.4/2013/8)

The committee concluded on the alignment for packing group III (and hazard class 8, the ADR classification for VCl3) with Skin corrosion Cat 1C.