Registration Dossier

Administrative data

Description of key information

VCl3 is very hygroscopic and gives, in contact of humidity :

VCl3 + H2O => VOCl + 2 HCL

VOCl + 1/2Cl2 => VOCl2

The dissolution reaction in water is instantaneous (half-life of VCl3 < 1 hour – VCl3 can be considered as a hydrolytically unstable substance), gives white fumes of HCl and the pH of the solution is < 2.

Due this physico-chemical property (HCl generation) and the weight of evidence (industrial practice), VCl3 is considered as corrosive and test for acute toxicity are not performed for animal welfare considerations

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

With the physico-chemical properties (HCl generation) and the weight of evidence (industrial practice), VCl3 is considered as corrosive and test for acute toxicity are not performed for animal welfare considerations. For this reason, no classification for acute toxicity could be set.

Some oral LD50 are collected but due the date of data (1965 and 1969) and the absence of details, these LD50 are not selected for classification (it is possible the cause of death is the effect of the corrosive property on the digestive tractus).