Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
CICAD 29: Vanadium pentoxide and other inorganic vanadium compounds
Author:
Dr M. Costigan, Mr R. Cary, Dr S. Dobson
Year:
2001
Bibliographic source:
World Health Organization
Reference Type:
secondary source
Title:
Effect on Organism of Vanadium Trioxide
Author:
IV Roshchin , AV Il'nitskaya , LA Lutsenko , LV Zhidkova
Year:
1965
Bibliographic source:
Fed. Proc. Transl. Suppl. 24, 611

Materials and methods

Principles of method if other than guideline:
No details
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No details
Specific details on test material used for the study:
No details

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No details

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No details
Doses:
No details
No. of animals per sex per dose:
No details
Control animals:
not specified
Details on study design:
No details

Results and discussion

Preliminary study:
No details
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 23 mg/kg bw
Based on:
element
Remarks:
Vanadium
Mortality:
No details
Clinical signs:
No details
Body weight:
No details
Gross pathology:
No details
Other findings:
No details

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The articles review cite a mouse oral LD50 value around 23 mg/kg body weight (as vanadium) for vanadium chloride. No further details are available.
Executive summary:

The articles review cite a mouse oral LD50 value around 23 mg/kg body weight (as vanadium) for vanadium chloride. No further details are available.