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Environmental fate & pathways

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The study of Mueller and Neumann (1981) assessed the biodegradability of L-histidine according to the Offhaus method. It was not performed according to GLP nor internationally accepted guidelines.

In this study, the biochemical oxygen demand (BOD) was analysed using a Sapromat BOD measuring unit. BOD5 was determined to be 517 mg O2/g for a substance having a COD value of 1023 mg O2/g. The test shows good biological degradation, i.e. 50 % biodegradation after 5 days.

Based on the observed respiration activity, the degradation should take place undisturbed, even at higher concentrations and especially after certain adaptation.

A second study on the biodegradability of L-histidine is available. In this study dating back to

1969, the ability of activated sludges from 3 municipal waste treatment plants to oxidise amino acids

was investigared. The activated sludge (concentration 2500 mg/L) was exposed to L-histidine at a

concentration of 500 mg/L. The biodegradation was assessed during 24h by measurement of the O2

consumption using Warburg flasks. The average biodegradation (as % of theoretical oxygen demand)

over the 3 activated sludges was 16.5 %.

The test was not performed according to GLP nor internationally accepted guidelines.