Registration Dossier
Registration Dossier
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EC number: 200-745-3 | CAS number: 71-00-1
Endpoint summary
Administrative data
Description of key information
Additional information
The study of Mueller and Neumann (1981) assessed the biodegradability of L-histidine according to the Offhaus method. It was not performed according to GLP nor internationally accepted guidelines.
In this study, the biochemical oxygen demand (BOD) was analysed using a Sapromat BOD measuring unit. BOD5 was determined to be 517 mg O2/g for a substance having a COD value of 1023 mg O2/g. The test shows good biological degradation, i.e. 50 % biodegradation after 5 days.
Based on the observed respiration activity, the degradation should take place undisturbed, even at higher concentrations and especially after certain adaptation.
A second study on the biodegradability of L-histidine is available. In this study dating back to
1969, the ability of activated sludges from 3 municipal waste treatment plants to oxidise amino acids
was investigared. The activated sludge (concentration 2500 mg/L) was exposed to L-histidine at a
concentration of 500 mg/L. The biodegradation was assessed during 24h by measurement of the O2
consumption using Warburg flasks. The average biodegradation (as % of theoretical oxygen demand)
over the 3 activated sludges was 16.5 %.
The test was not performed according to GLP nor internationally accepted guidelines.
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