Registration Dossier

Physical & Chemical properties

Vapour pressure

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
QSAR using an accepted calculation method. The assessed substance is within the domain of the QSAR.
Qualifier:
no guideline followed
Principles of method if other than guideline:
QSAR calculation
GLP compliance:
no
Type of method:
other: QSAR
Key result
Temp.:
25 °C
Vapour pressure:
0 mm Hg
Remarks on result:
other: Neely, WB and Blau, GE (1985)
Conclusions:
VP: 5.99E-09 mm Hg.
The vapour pressure was calculated by EpiSuite's MPBPVP model.
Executive summary:

The vapour pressure was calculated by EpiSuite's MPBPVP model and found to be 5.99E-09 mm Hg.

This corresponds to a vapour pressure of 7.99E-07 Pa.

L-histidine is considered to be inside the applicability domain of the EpiSuite MPBPVP model since the following criteria are fulfilled:

- the molecular weight of L-histidine is within the molecular weight range of the training set

- L-histidine has a limited number of functional groups

- all functional groups present in L-histidine are represented in the training set and have a fragment coëfficiënt available.

Description of key information

VP: 5.99E-09 mm Hg. (estimated by QSAR). This corresponds to a vapour pressure of 7.99E-07 Pa.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure was calculated by EpiSuite's MPBPVP model and found to be 5.99E-09 mm Hg.

The suitability of the model was assessed and it was concluded that L-histidine is considered to be inside the applicability domain of the EpiSuite MPBPVP model.