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PBT assessment

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PBT assessment: overall result

Reference
Name:
L-histidine
Type of composition:
legal entity composition of the substance
State / form:
solid: particulate/powder
Related composition:
Composition 3
Reference substance:
Composition 1
PBT status:
the substance is not PBT / vPvB
Justification:

L-histidine was determined to be rapidly biodegradable based on the result of the study of Mueller and Neumann (1981) showing 50% degradation after 5 days.

Bioaccumulation of L-histidine can be excluded based on its low log Kow of -3.32

L-histidine is not classified as carcinogenic, mutagenic, toxic for reproduction or Specific Target Organ Toxicity after repeated exposure according to Regulation EC No. 1272/2008 (CLP). L-histidine was determined not to be aquatic toxic based on the NOEC values in daphnia (>= 100 mg/L) and algae (10 mg/L).