Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
No guideline study with some deficiencies: the rat is a poor animal for the study of experimental hypercholesteremia, requiring special diets and the feeding of cholesterol and saturated fats to develop high serum levels. The data on changes in serum cholesterol with age are incomplete.

Data source

Reference
Reference Type:
publication
Title:
Serum Cholesterol Levels in Rats Fed Thirteen Trace Elements
Author:
Schroeder HA
Year:
1968
Bibliographic source:
J. Nutrition, 94: 475-480

Materials and methods

Type of study / information:
Study of the effect of Zr sulfate administration via drinking water on serum cholesterol levels in rats.
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were given soluble salts of zirconium (5 ppm Zr) from the time of weaning until 11 to 30 months of age.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Zirconium sulfate

Results and discussion

Any other information on results incl. tables

Serum cholesterol levels in mature rats given zirconium (12 rats/sex tested; age of rats: 893 days):

male rats: 89.7 ± 5.6 mg/100 mL

female rats: 100.7 ± 9.0 mg/100 mL

Compared with the controls given 1.0 ppm chromium, values for males were slightly elevated in the group fed zirconium.

Female control levels were the highest of any group. Other elevated values (> 100 mg/100 mL) occurred in the group given zirconium.

The observed effects were not significant.

Changes in circulating cholesterol levels with age: Increases occurred in rats of both sexes fed zirconium.

Applicant's summary and conclusion

Conclusions:
Compared with the controls given 1.0 ppm chromium, values for males were slightly elevated in the group fed zirconium.
Female control levels were the highest of any group. Other elevated values (> 100 mg/100 mL) occurred in the group given zirconium.
The observed effects were not significant. Increases in circulating cholesterol levels with age occurred in rats of both sexes fed zirconium.