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EC number: 238-694-4
CAS number: 14644-61-2
The study from Harris (2014b) using zirconium sulfate as test substance indicates that zirconium was not available to the aquatic test organisms because all zirconium precipitated from the water column. The study yielded a 48-h EC50 > 100 % v/v saturated solution. A study with the insoluble read across substance zirconium dioxide yielded a similar 48-h EC50 of 100 mg/L (Bazin, 1994). These two studies were used in a weight of evidence approach to cover the endpoint.
Three studies were included in the dossier, two of which were used in a
weight of evidence approach for endpoint coverage.
In the study of Harris (2014b), in which the acute toxicity of zirconium
sulfate to Daphnia magna was investigated, the range finding test
indicated no mortality at the highest concentration tested, i.e. a 100 %
v/v saturated solution. Since no dissolved zirconium above the LOQ (20
µg Zr/L) could be detected in the 100% v/v saturated solution, no final
test was performed and the 48-h EC50 was considered to be > 100 % v/v
saturated solution of zirconium sulfate.
Because of the precipitation of zirconium at environmentally relevant
conditions, it is considered justified to perform read across from
insoluble zirconium substances such as zirconium dioxide (for further
argumentation reference can be made to the read across document attached
to IUCLID Section 13). Therefore, a weight of evidence approach is
suggested using the study from Harris (2014b) described above and a
study performed with the insoluble zirconium dioxide (Bazin, 1994). This
study yielded a 48-h EC50 of > 100 mg/L (based on nominal initially
added zirconium dioxide) and confirms that the toxicity of the 'water
soluble' zirconium sulfate and the insoluble zirconium dioxide is very
Finally, the study of Borgmann et al. (2005) studied juveniles of the
amphipod species Hyalella azteca, following an atypical procedure. In
this study, 7-d (acute) toxicity tests were performed. The obtained LC50
values in soft water and moderately hard tap water were > 1000 and >
3150 µg Zr/L, based on nominal concentrations. However, based on
analytical measurements in the soft water assay, only a limited amount
of the added zirconium was present in the dissolved fraction (e.g., 4.2
µg Zr/L at the nominal concentration of 1000 µg Zr/L). Because of
non-satisfactory analytical monitoring, no exact LC50 values based on
measured zirconium concentrations could be calculated. Moreover, the
animals were fed during the test, which is not a common practice in
acute toxicity tests. The results are therefore not considered reliable
(Klimisch 3). The study is therefore considered as a supporting study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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