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EC number: 701-028-2 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report Date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Test material form:
- liquid
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0, 25, 50, 100%
- No. of animals per dose:
- 3
- Details on study design:
- After an acclimation period of 5 days, animals were randomly selected into cages and assigned a number. All animals were nulliparous and not pregnant. The mice were 8-12 weeks old at the start of the study. Based on a preliminary screening study that found no systemic toxicity or excessive loirritation, doses were set at 25%, 50%, and 100% concentrations. A control group was run in the vehicle only.
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 25% - 1.5250% - 2.47100% - 0.87
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 0% (Vehicle) - 2254.5925% - 3435.0350% - 5559.62100% - 1970.86
Any other information on results incl. tables
Conc | dpm/ node | Test / Control Ratio | Result |
Blank | 2254.59 | N/A | N/A |
25% | 3435.03 | 1.52 | Negative |
50% | 5559.62 | 2.47 | Negative |
100% | 1970.86 | 0.87 | Negative |
EC3 value = Not established (all concentrations negative). | |||
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- TNPP was not sensitising at all concentrations (25, 50 and 100%).
- Executive summary:
This study indicates that TNPP is not a skin sensitiser.
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