tris (4-nonylphenol, branch) phosphorous acid ester

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The report was scientifically acceptable.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1957

Report date:

1957

Reference 2

Reference Type:

publication

Title:

No information

Author:

Miller, L.C., Tainter, M.L.

Year:

1944

Bibliographic source:

Proc. Soc. Exptl. Biol. And Med., 57, 261

Materials and methods

Test guideline

Deviations:

not specified

Principles of method if other than guideline:

Method: other: see below

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-(2-methyloctyl)phenyl bis(4-nonylphenyl) phosphite

EC Number:

701-028-2

Cas Number:

26523-78-4

Molecular formula:

C45H69O3P

IUPAC Name:

4-(2-methyloctyl)phenyl bis(4-nonylphenyl) phosphite

Constituent 2

Reference substance name:

Nonylphenol

EC Number:

246-672-0

EC Name:

Nonylphenol

Cas Number:

25154-52-3

IUPAC Name:

2-nonylphenol

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS- Diet: ad libitum - Water: ad libitum

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

cotton seed oil

Details on oral exposure:

Fifty young adult albino rats (5 males and 5 females/group) were fasted for 18 +/- 2 hours and given 5 graded doses (8.19 to 32.72 grams/kg) of TNPP. The sample was prepared as 50% solution in cottonseed oil and doses were administered by stomach tube.

Doses:

8.19 - 11.32 - 16.38 - 22.62 - 32.72 g/kg bw.

No. of animals per sex per dose:

50

Control animals:

other: needed for data submission

Details on study design:

- Duration of observation period following administration: 14 days- Necropsy of survivors performed: yes. Rats that died as well as survivors sacrificed at the end of the experiment were examined for evidence of gross pathology.

Statistics:

The LD50 was computed according to the method of Miller and Tainter.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

16 200 - 21 800 mg/kg bw

Mortality:

Mortality resulted at scattered intervals over the first five days.

Clinical signs:

other: All rats showed evidence of abdominal pain and catharsis after dosage. Higher doses resulted in urinary incontinence and prostration.

Gross pathology:

Gross pathological findings included hemorrhagic lesions in the gastric mucosa and/or duodenum in a few rats that died and hemorrhagic lungs.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated informationCriteria used for interpretation of results: expert judgment

Conclusions:

LD50 calculated to be 19500 +/- 3300 mg/kg. These

Executive summary:

LD50 calculated to be 19500 +/- 3300 mg/kg.