Registration Dossier
Registration Dossier
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EC number: 701-028-2 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Acute intraperitoneal LD50 in rat, Test n° 831156, TK 10417 (Irgafos TNPP)
- Author:
- Kobel
- Year:
- 1 983
- Bibliographic source:
- Ciba-Geigy Limited.
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Tris(nonylphenyl) phosphite
- EC Number:
- 247-759-6
- EC Name:
- Tris(nonylphenyl) phosphite
- Cas Number:
- 26523-78-4
- Molecular formula:
- C45H69O3P
- IUPAC Name:
- Phenol, nonyl-, phosphite (3:1)
- Details on test material:
- other TS: Trisnonylphenyl phosphite
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAIf(SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Age at study initiation: 7-8 weeks - Weight at study initiation: 195 to 240 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80.
- Details on exposure:
- Single dose of 1000 mg/kg bw, by intraperitoneal injection.
- Doses:
- one single dose
- No. of animals per sex per dose:
- 10
- Control animals:
- other: needed for data submission
- Details on study design:
- - Duration of observation period following administration: Mortality and symptoms were observed daily for 14 days - Frequency of observations and weighing: 80 Animals were weighed at day 1, 7 and 14.- Necropsy of survivors performed: yes, the animals were submitted to a gross necropsy at the end of the observation period.
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- Dyspnoea, exophtalmus, ruffled fur and curved body position were seen, being common symptoms in acute tests. Animals recovered within 12 days.
- Body weight:
- No data
- Gross pathology:
- At autopsy, peritoneal adhesions in the liver and spleen area were found in 8/10 animals.
Applicant's summary and conclusion
- Conclusions:
- LD50 (ip) >1000 mg/kg.
- Executive summary:
LD50 (ip) >1000 mg/kg.
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