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EC number: 701-028-2
CAS number: -
Body weights were significantly reduced in the leptofos group (to 64%)
and TOCP group (to 87%) with no effects in the Polygard group. Food
intake was significantly higher in the Polygard groups in the second,
third and fourth week, while leptofos induced a lower food intake.
Animals in the leptofos and TOCP group showed signs of delayed
neurotoxicity. Cholinesterase activity was not changed in any of the
groups on all days. TOCP and leptofos showed degenerative changes in the
axons and myelin sheath in the spinal cord and peripheral nerves. No
degenerated axons were found in the control and Polygard group.
Histological investigations of the other organs resulted in no effects
caused by the different treatments.
Polyguard R (mixture of nonylphenol phosphites) did not produce
neurotoxicity in hens.
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