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EC number: 215-710-8
CAS number: 1344-95-2
The acute oral administration of >=5000 mg calcium silicate/kg bw failed to produce signs of toxicity or deaths in treated animals. Based on structure analogy to SAS, the acute inhalation of Ca silica dust may cause discomfort and dyspnea as well as transient signs of local irritation to nasal, bronchiolar and ocular mucous membranes.
Summary of acute
Based on experimental results from
CS and the structure-analogous SAS, there is ample evidence that high
oral doses of CS do not exert any significant toxicity in experimental
corresponding studies with CS have been located. On
the other hand, experimental data is available about structure-analogous
silicas (SAS) which resulted in no mortality under test conditions.
Summary of results obtained with
All acute inhalation
studies performed with dry dust of SAS were hampered by the
technical problem to achieve the
recommended highest test
concentration of 5 mg/L, apparently attributable to the high adhesive
forces which caused rapid precipitation onto equipment walls. Therefore,
the maximum attainable chamber concentrations were distinctly lower than
one study, all ten rats (5 m, 5 f) survived when exposed to an average
concentration of 2.08 mg/L of pyrogenic SAS, Cab-O-Sil M5, (MMAD = 0.76
µm) for 4 hours. Clinical symptoms were nasal discharge during exposure,
in a few animals crusty eyes and nose as well as alopecia at days
post-exposure. No macroscopic organ lesions were noted but in one animal
discoloration of the lungs was observed [Cabot 1981].
a further study, an
average dust concentration of 0.691 mg/L (range 0.650 – 0.725 mg/L) for
the precipitated SAS, Sipernat 22,
was obtained, with a
respirable mass fraction of some 45 to 47 % accounting for particles
with a mass median aerodynamic diameter (MMAD) of less than 5 µm
[Degussa 1983]. No clinically and pathologically meaningful effects were
observed after 4-h exposure
of rats (5 m, 5 f, each).
The animals showed signs of some discomfort and stress, and body weight
of females was retarded for two days post-exposure.
amorphous silicates and silicas (SAS) are practically non-toxic by all
routes of exposure. Aerosol levels that were technically achievable for
SAS under experimental conditions are acutely non-toxic and clearly
sub-lethal (=< 2 mg/L). Under
comparable testing conditions we expect that synthetic amorphous calcium
silicate shows the same behaviour.
classification for acute human health hazards shall be required.
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