Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Approx. 20 years of experience from exposed workers gave no evidence of skin sensitisation/allergic contact dermatitis in conjuction with exposure to calcium silicate (see also Chapter 7.10.4). This is consistent with approx. 50 years of occupational experience with synthetic amorphous silica, the parent substance (see ECETOC 2006).

Further testing has been waived based on REACH Regulation, Annex XI.


Migrated from Short description of key information:
No experimental data in animals available. There is no evidence of skin sensitisation in exposed workers over decades of practical experience.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
No experimental data available. There is no evidence of respiratory sensitisation after approx. 50 years of experience from workers exposed to calcium silicate or silica.

Justification for classification or non-classification