Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-710-8
CAS number: 1344-95-2
Silicic acid, calcium salt is an inorganic solid which is insoluble in
n-octanol. Due to its inherent physicochemical properties
bioaccumulation is not expected.
Log Kow result are not available due to the inorganic nature of the
As the substance is poorly soluble, low concentrations are expected in
the aquatic compartment. Low quantities which might be taken up are
considered to be not bioavailable. Absorbed Si levels are known to be
rapidly excreted in urine and faeces. Thus,calcium silicate contains no
After oral ingestion, there is no accumulation of synthetic amorphous
silica in body tissues. Upon cessation of exposure rapid elimination
occurs. Intestinal resorption appears to be insignificant in animals and
humans, the small apparent increases in the urine output of human
volunteers were remarkably low as compared with the high dose of 2500 mg
SiO2 applied subcutaneously are subjected to rapid dissolution and
The inorganic nature of calcium silicate precludes the possibility of
There are no concerns regarding toxic effects in any of the
(eco-)toxicological studies, short or long term, carried out on the test
substance and any analogues. This would indicate that the substance is
unlikely to bioaccumulate within biological tissues.
EC10 or NOEC ≥ 0.01 mg/L for marine / freshwater organisms (long-term
The substance is not classified as carcinogenic (category 1 or 2),
mutagenic (category 1 or 2), or toxic for reproduction (category 1, 2 or
3) according to Directive 67/548/EEC or carcinogenic
(category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic
for reproduction (category 1A, 1B or 2) according to Regulation EC No
There is no other evidence of chronic toxicity, as identified by the
classifications T, R48 or Xn, R48 according to Directive 67/548/EEC or
specific target organ toxicity after repeated exposure (STOT RE category
1 or 2) according to Regulation EC No 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Damit Sie die Website optimal nutzen können, verwenden wir Cookies.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again