Registration Dossier

Administrative data

Description of key information

Experimental studies gave no evidence of skin irritation. Slight to moderate transient irritation to the eye that may occur is not relevant for classification.  

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

No studies on calcium silicate (CS) have been located.

The structure-analogous substances, synthetic amorphous sodium aluminum silicates (NAS), failed to produce irritation of rabbits´ skin. Ocular effects were variable in several studies: Initial conjunctival irritation was observed following instillation of NAS powder into rabbits´ eyes without involvement of the cornea and iris (JM Huber 1978). More pronounced effects were observed in another study (PPG 1975): The slight to moderate eye reactions were reversible within 3, 7 or 14 days.

It can be concluded that based on current numerical standards of assessment (EU, GHS), no classification is required.

Irritation to the respiratory sytem is related to deposition of particles, but is no particular inherent property of silica / silicates.


Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

For synthetic amorphous calcium silicate as structure-analogous substance to NAS no classification for skin an eye irritation is required.