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EC number: 215-710-8
CAS number: 1344-95-2
In a 2-y feeding study, no increase in tumors found. No carcinogenic potential observed with sodium aluminium silicate (NAS) in a rat carcinogenicity model after intra-pleural treatment, as well as in a long-term feeding study with a structure-analogous silica in mouse and rat.
see Discussion above: no carcinogenic potential
There was no evidence of a
carcinogenic potential in a 2-y feeding study using calcium silicate
(Columbia 1956, see also 7.5.1).
However, the number of animals was
too small as to deliver sufficiently robust results for biostatistical
Negative results were found after
long-term oral administration of the structure-analogous synthetic
amorphous silica (SAS) (up to 5 % in the diet given to rats and mice,
corresponding to average daily doses of 2000 mg/kg bw in rats and 4500
to 5800 mg/kg bw in mice, female and male, respectively) [Takizawa et
Negative findings in a rat
carcinogenicity model after intra-pleural treatment with various types
of materials (including sodium-aluminium silicate, NAS, a structure
analogue of calcium silicate) [Unilever 1995] and the absence of a
mutagenic potential underline that the cancerogenic potential of
synthetic amorphous calcium silicate can be considered as negligible .
In synopsis of all studies, it is
concluded that there is no evidence of a carcinogenic potential arising
from ingestion calcium silicate.
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