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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.

Data source

Reference
Reference Type:
review article or handbook
Title:
Toxicology of the Eye (3rd ed)
Author:
Grant WM
Year:
1986
Bibliographic source:
Charles C. Thomas Publisher, Springfield, pag 518

Materials and methods

Type of study / information:
Tests on human eyes
Endpoint addressed:
eye irritation
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
No details on test material identity are available.

Method

Ethical approval:
not specified
Details on study design:
Three solution of tartaric acid at concentration 0.16 M was partially neutralized with sodium phosphate respectly to pH 3, pH 4, pH 5 and tested to human eyes.
Exposure assessment:
not specified

Results and discussion

Results:
Dilute solutions of tartaric acid has at times been employed as eye washes with the aim of counteracting the effects of alkalies in alkali burns. Tests on human eyes of 0.16 M tartaric acid partially neutralized to pH 3 with sodium phosphate caused severe stinging but no injury. When adjusted to pH 4, it caused mild to
moderate stinging, and at pH 5 caused only slight discomfort.

Applicant's summary and conclusion

Conclusions:
Dilute solutions of tartaric acid has at times been employed as eye washes with the aim of counteracting the effects of alkalies in alkali burns. Tests on human eyes of 0.16 M tartaric acid partially neutralized to pH 3 with sodium phosphate caused severe stinging but no injury. When adjusted to pH 4, it caused mild to
moderate stinging, and at pH 5 caused only slight discomfort.
Executive summary:

Dilute solutions of tartaric acid has at times been employed as eye washes with the aim of counteracting the effects of alkalies in alkali burns. Tests on human eyes of 0.16 M tartaric acid partially neutralized to pH 3 with sodium phosphate caused severe stinging but no injury. When adjusted to pH 4, it caused mild to moderate stinging, and at pH 5 caused only slight discomfort.