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Physical & Chemical properties

Particle size distribution (Granulometry)

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Description of key information

The laser diffraction tests performed to conduct particle size distribution studies on three samples originating from different producers of the substance Potassium Sodium Tartrate tetrahydrate, with purities above 99%, indicate a mass median aerodynamic diameter of 73.4 - 88.5 micrometers. A maximum of 4.14% of the particles have a diameter below 10 micrometers, corresponding to the respirable fraction.

Additional information

The MMAD of the worst-case commercial granular presentations of the product lies between 73.4 and 88.5 µm, well above the fraction fraction known as respirable, that may reach the lower respiratory tract. Although a maximum of 4.14% of the substance in the granular solid corresponds to particles with a diameter below 10 µm, and almost 50% of the total particles have a diameter below 100 microns, it is considered that in the event of exposure to dust, the majoruty of the substance will be retained in the mouth and upper airways, being refluxed into the digestive system. The very low oral toxicity of the substance, it non classification as an eye or dermal irritant and supporting occupational exposure studies which do not indicate respiratory problems or toxicity even at high dust exposures (see corresponding sections in dossier and CSR) do not justify in vivo inhalation toxicity testing of this substance.