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EC number: 236-337-7
CAS number: 13308-51-5
Experimental data on the acute toxicity of Boron orthophosphate
(CAS 13308-51-5) are available for fish, daphnia and algae. All three
studies show no toxicity up to 100 mg/L nominal test concentration. The
test substance revealed low water solubility in the test media. In all
aquatic toxicity tests, the test substance achieved the maximum
solubility in all test media under the test solution preparation
methods, but the dissolved boron concentrations increased with
increasing of the nominal test concentrations and did not achieve
saturation. Thus, the test results are reported with both nominal test
substance concentrations and the measured boron concentrations
respectively. Since no effects observed in either short-term or
long-term tests of three trophic levels, it can be concluded that no
aquatic toxicity was found under the test conditions. .
The acute toxicity of Boron orthophosphate to fish (Danio rerio)
was conducted according to OECD 203 (Simon, 2015) under semi-static
conditions. The test solutions were freshly prepared by adding
respective amount of test substance to dilution water. Subsequently the
insoluble parts were separated by filtration using 0.2 µm
membrane. There were no concentration-dependent effects on survival up
to the highest nominal test substance concentrations of 100 mg/L , which
correspond to the measured concentration of 0.207 mg boron per liter
(96h LC50 > 0.207 mg boron/L (meas. arithm. mean)).
The acute toxicity of Boron orthophosphate to Daphnia magna was
determined in a study following OECD 202 (Simon, 2014) under static
conditions. The test solutions were freshly prepared by serial dilution
of supernatant solution prepared with 100 mg/L of nominal test substance
concentration. There were no concentration-dependent effects on
immobilization up to the highest nominal test substance concentration of
100 mg/L, corresponding to 0.135 mg boron per liter (48h EC50 > 0.135
mg boron/L (meas. arithm. mean).
The influence of Boron orthophosphate (CAS 13308-51-5) on growth
of the freshwater green alga Pseudokirchneriella subcapitata was
investigated in a static OECD 202 test under GLP conditions (Simon,
2014). The test solutions were freshly prepared by serial dilution of
supernatant prepared with 100 mg/L of nominal test substance
concentration and growth rate of algae. The test was terminated after 72
hours. There were no concentration-dependent effects on the growth of
the green algae up to the highest test concentrations of 1.35 mg
boron/L. The ErC50 and EyC50 values for inhibition of growth rate and
yield were set to be > 1.35 mg boron/L (> 100 mg/L nominal). Based on
the growth a NOEC ≥ 1.35 mg boron/L (meas. initial) and > 100 mg/L
nominal test substance concentration was observed.
Experimental data on the long-term toxicity of Boron
orthophosphate (CAS 13308-51-5) to aquatic invertebrates are available.
Daphnia magna was exposed to Boron orthophosphate in a semi static OECD
211 test under GLP conditions (Simon, 2016). The highest test solution
with 3.75 mg/L nominal test substance concentration was freshly prepared
by addition method and the other test solutions were using serial
dilution of supernatant prepared with 1.5 mg/L of nominal test substance
concentration. No adverse effects were observed in the test. The NOEC is
≥ 3.75 mg /L (nominal test substance concentration) and ≥ 494 µg test
The influence of Boron orthophosphate (CAS 13308-51-5) on the
respiration of activated sewage sludge was investigated in a static OECD
209 test under GLP conditions (Simon, 2015). The effect of Boron
orthophosphate on the respiration of activated sewage sludge gave a 3h-
EC50 of greater than 1000 mg/L. The EC20 (3h) was determined to be ≥
1000 mg/L (nominal test substance conc.). No significant inhibition of
bacterial respiration by Boron orthophosphate up to and including a
concentration of 1000 mg/L was observed.
Based on the available information Boron orthophosphate (CAS
13308-51-5) is considered not having short-term or long-term toxicity to
aquatic organisms under environmental conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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